Lynx Bioscience LLC

Identification of NAMPT as primary target of neuroprotective drug P7C3 using combination of click chemistry and chemical proteomics approach.


P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Wang G, Han T, Nijhawan D, Theodoropoulos P, Naidoo J, Yadavalli S, Mirzaei H, Pieper AA, Ready JM, McKnight SL. Cell. 2014 Sep 11;158(6):1324-1334. PMID: 25215490.